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KMID : 0360319910230040806
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Journal of Korean Cancer Research Association
1991 Volume.23 No. 4 p.806 ~ p.813
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Combination Chemotherapy with Cyclophosphamide, Vincristine, Procarbazine, Prednisone (C-MOPP) in Hodgkin´s Disease
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Abstract
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Between November 1977 and December 1987, the combination chemotherapy with cyclophosphamide, vincristine, procarbazine, and prednisone (C-MOPP) had been administered in 29 patients with stage III-IV Hodgkin´s disease or recurrent cases after radiotherapy. Among 28 evaluable patients, 20 patients(71.4%) achieved complete responses and 8 patients(28.6%) had partial reaponses. The overall 5-year survival rate was 50.3% and the 5-year disease-free survival of complete responders was 55.7%. The frequent nonhematologic toxicties(WHO criteria gradezII) were alopecia(96.4%) and nausea/vomiting(42.8%) but hematologic toxicities were minimal. In conclusion, C-MOPP regimen was effective and well tolerated for the treatment of stage III-IV and recurrent Hodgkin´s disease.
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KEYWORD
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